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Salixin®

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Sustainably and renewably sourced purple will bark extract which contains healing salicylates and polyphenols

High performance keratin derived actives for hair & scalp repair

Advanced bioprocessing and sustainable sourcing of therapeutic fucoidan from seaweed

Virgin oil and extracts with unique protective properties from the Arabian Peregrina tree

Trifarotol™

Patent Pending

The only 4th generation retinoid for cosmetic use

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INCI

Trifarotenyl Caprylate

Overview

Trifarotol™ is the newest retinoid in the beauty industry and the only one of its class available for cosmetic use without a prescription.

This 4th generation retinoid bio-transforms with the skin’s own enzymes to gently deliver active trifarotene into the skin layers where it binds selectively to RAR-γ. Targeted binding makes Trifarotol gentler and safer than retinoids that activate RAR-⍺ and RAR-β while still maintaining efficacy. The result? Skin that looks smoother, brighter, and younger, without irritation.

Selective RAR-γ stimulation normalizes cell turnover, reduces inflammation, increases collagen synthesis, and improves the various signs of photoaging. It’s powerful enough to visibly soften fine lines and improve texture, yet gentle enough for nightly use.

Benefits

Improves signs of aging and global skin appearance
Gentle enough for daily use
Launch without the hassle of OTC or Rx regulations
Oxidative stability: easy to formulate with, no additives, no degradation, no special handling, packaging or filling

Bioactive Rationale

Selective Binding

Retinoids bind to and activate retinoic acid receptors (RARs) in the skin. Different types of retinoids activate different types of receptors (RAR-⍺, RAR-β, or RAR-𝛾) located in specific layers of the skin. Activation leads to various skin benefits depending on which receptor is engaged, and can result in normalized cell turnover, reduced inflammation, increased collagen synthesis, and improvement in the signs of photoaging.

Trifarotol is the latest retinoid for the beauty industry and the only one of its class available for cosmetic use without a prescription. This ingredient bio-transforms with the skin’s own enzymes to gently deliver active trifarotene into the skin layers where it binds selectively to RAR-𝛾.

Selective binding to RAR-𝛾 makes Trifarotol gentler and safer than retinoids that activate RAR-⍺ and RAR-β while maintaining efficacy.

Clinical Results

Visible results, proven gentle

In a 12-week clinical study, subjects experienced significant improvements in skin smoothness, clarity, tone, and overall appearance with 100% agreeing the ingredient felt gentle on their skin. Even delicate eye-area wrinkles visibly improved over time.

Study Design

•10-subject pilot
•Ages 35-65
•12 weeks, once daily use (PM)

Expert-Graded Results

After 8 weeks, visible improvements were observed with results continuing to increase through 12 weeks:

Skin smoothness and texture improved by 29.6%
Overall skin appearance improved by 27.1%
Skin clarity improved by 34.5%
Evenness of skin tone improved by 21.8%
Fine lines and wrinkles showed visible improvement by 8.9%

All results were statistically significant (p < 0.05).

Eye Area Results

Visible improvement in the appearance of eye-area wrinkles was observed after 12 weeks of use, demonstrating effectiveness even on delicate skin zones.

Consumer Self-Perception (12 Weeks)

Participants reported high levels of satisfaction and skin comfort:

100% agreed the product felt gentle on skin
100% agreed skin tone looked more uniform
80% agreed skin clarity was improved
80% agreed skin texture was improved
70% agreed the appearance of fine lines was reduced

Formulation Guidelines

Suggested Use Level

100 ppm

Procedure

Add to oil phase and heat to 80-85°C

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