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TXVector is the first of its kind anti-aging depigmentation active for a naturally even skin tone. Studies showed reduced redness in two weeks and reduced dark spots in four weeks.
INCI
Cetyl Tranexamate Mesylate
Physical Description
White Powder
Applications
Key Benefits
Key Results
Bioactive Rationale
Tranexamic Acid (TXA) is a third-generation bioactive that prevents and soothes both redness and dark spots.
External skin disruptors (UV light, shaving, stripping solvents, detergents, etc.) cause the keratinocytes in the epidermis to produce signal mediators (e.g., plasminogen). These mediators initiate a cascade of events in the skin including inflammation, atypical plasmin activity, proliferation of keratinocytes, desquamation, melanocyte differentiation, increased tyrosinase activity, and transfer of melanosomes to upper layers. The result is unevenly pigmented, dull skin.
TXA inhibits plasmin activity, decelerating the above processes while promoting a more uniform skin tone and faster skin barrier recovery. However, the permeability of TXA through the skin is insufficient due to its hydrophilic nature and strong hydrogen-bonding capacity. Esters of TXA offer a higher level of skin-targeting, and epidermal esterases can break down TXA esters to the active TXA form. TXA esters are known skin permeation enhancers and may boost the efficacy of other active ingredients.
TXVector is a smart delivery form of TXA that is notably easier to formulate compared to other TXA esters. It also works as the primary emulsifier (o/w). TXVector can be dissolved and dispersed in water, and remains stable over time without separation or aggregation. One part of TXVector delivers ≈0.33 part of TXA.
Safe for Skin
A Human Repeat Insult Patch Test (HRIPT) study with 54 healthy male and female adult volunteers investigated the irritation and sensitization potential of TXVector Lightening Serum 01-82 containing 2% TXVector. None of the subjects presented adverse events or reactions to the test article. The study concluded that the serum containing TXVector is clinically proven to be safe for skin. This study was performed by Princeton Consumer Research in the UK, and it is available upon request.
Effective on the Skin
An 8-weeks clinical study on 35 women with self-assessed uneven skin tone, age spots, and redness evaluated the efficacy of TXVector Lightening Serum 01-82 containing 2% TXVector. Volunteers applied the serum at home, twice daily, followed by sunscreen SPF 50 during the day. Volunteers did not use other similar bioactives throughout the study. Product performance was assessed by Mexameter®, photography, and self-perception questionnaires. This study was performed by Princeton Consumer Research in the UK, and it is available upon request.
Instrumental Evaluation
Melanin and erythema indexes were measured using a Mexameter® MX18. This probe measures light absorption and reflection in an area of 19.6 mm2 on the skin surface. Volunteers were assessed in one facial spot for melanin and in another facial spot for erythema (redness). The same spots were measured at each time point.
Melanin is measured by two specific wavelengths (red: 660 nm and infrared: 880 nm) chosen to correspond to different absorption rates by the pigments.
For erythema, two specific wavelengths are used (green: 568 nm and red: 660 nm) corresponding to the spectral absorption peak of hemoglobin and to avoid other color influences (e.g., bilirubin).
© 2023 / All rights reserved / Actera Ingredients
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