Hydroxysomes® Adenosine

Novel Adenosine Delivery System for Hair Growth

Man-Hair
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INCI

Adenosine (and) Hydroxyapatite

Overview

Adenosine is a cosmetic active which significantly improves hair density and thickness when applied to the scalp. Pure adenosine has known dermal penetration challenges which can impede efficacy. To overcome this and achieve superior results, adenosine is delivered inside microscopic calcium particles that penetrate into deeper layers of the scalp.

White powder
  • Suggested use level: minimum 1.5% for best efficacy
  • Add below 40°C in formulas at or above pH 5.5. Disperse solids into any system. Mix until homogenous.

Active ingredient delivery via calcium microparticles allows adenosine to penetrate into deeper layers of the skin. The skin’s naturally acidic pH bio-erodes the microparticles, releasing active adenosine for a continuous, long lasting effect. This process simultaneously releases calcium nutrients to the scalp which help rebalance and strengthen the skin barrier.

Adenosine has been shown to stimulate the expression of fibroblast growth factor-7 (FGF-7) and keratinocyte growth factor (KGF) in cultured human dermal papilla cells. These elements support an environment for growing longer, thicker hairs. Scalp treatment with adenosine helps increase the number of hair follicles that are in the growth period of the hair growth cycle, known as the anagen phase. It also inhibits the activation of the transition phase (catagen phase) where hair growth stops prior to resting and eventually falling. The ratio of thick hairs

to thin hairs is also significantly increased as more follicles produce thicker hairs and less produce thin or vellus hair. Vellus hair is the fine, light, short hair that is known to increase in cases of hair thinning or baldness where a global loss in longer, thicker terminal hair is observed. The above factors work synergistically to improve overall hair density and thickness, significantly improving the effects of hair thinning and hair loss in men and women.

Adenosine is clinically proven to increase hair thickness and density. Validated by dermatologist assessment and subject self-perception.

Topical adenosine increases the ratio of hairs that are actively growing.

In an in-vitro study on isolated human hair follicles, adenosine was shown to extend the anagen (growth) phase of the hair cycle and block the effects of catagen-inducing growth factors within 6 days.

Adenosine improves the thick-to-thin hair ratio in both men and women.

In a double blind, placebo-controlled clinical study on 30 adult women affected by female pattern hair loss, adenosine was proven to significantly increase the thick-to-thin hair ratio. The adenosine user group reported a strong positive favor for the treatment product and no adverse effects were observed.

Adenosine treatment improves global hair thinning.

A double-blind, randomized clinical study on 102 adult men with male pattern hair loss showed a significant improvement in global thinning as determined by clinical dermatologist grading. The treatment product was superior to placebo formula in all parameters including percentage of thick hairs and perception of hair thickness by participants’ self-assessment. No causative adverse effects were reported.

In all clinical studies, adenosine samples were reported to have no or very few adverse effects compared to Minoxidil which commonly causes contact dermatitis and irritation on the scalp and along the hairline.

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